The early modern era was marked by a number of significant changes in the understanding of reason, starting in Europe. One of the most important of these changes involved a change in the metaphysical understanding of human beings. Scientists and philosophers began to question the teleological understanding of the world. Nature was no longer assumed to be human-like, with its own aims or reason, and human nature was no longer assumed to work according to anything other than the same "laws of nature" which affect inanimate things. This new understanding eventually displaced the previous world view that derived from a spiritual understanding of the universe. René Descartes Accordingly, in the 17th century, René Descartes explicitly rejected the traditional notion of humans as "rational animals", suggesting instead that they are nothing more than "thinking things" along the lines of other "things" in nature. Any grounds of knowledge outside that understanding was, therefore, subject to doubt. In his search for a foundation of all possible knowledge, Descartes deliberately decided to throw into doubt all knowledge—except that of the mind itself in the process of thinking: At this time I admit nothing that is not necessarily true. I am therefore precisely nothing but a thinking thing; that is a mind, or intellect, or understanding, or reason—words of whose meanings I was previously ignorant. This eventually became known as epistemological or "subject-centred" reason, because it is based on the knowing subject, who perceives the rest of the world and itself as a set of objects to be studied, and successfully mastered by applying the knowledge accumulated through such study. Breaking with tradition and many thinkers after him, Descartes explicitly did not divide the incorporeal soul into parts, such as reason and intellect, describing them as one indivisible incorporeal entity. A contemporary of Descartes, Thomas Hobbes described reason as a broader version of "addition and subtraction" which is not limited to numbers. This understanding of reason is sometimes termed "calculative" reason. Similar to Descartes, Hobbes asserted that "No discourse whatsoever, can end in absolute knowledge of fact, past, or to come" but that "sense and memory" is absolute knowledge. In the late 17th century, through the 18th century, John Locke and David Hume developed Descartes's line of thought still further. Hume took it in an especially skeptical direction, proposing that there could be no possibility of deducing relationships of cause and effect, and therefore no knowledge is based on reasoning alone, even if it seems otherwise. Hume famously remarked that, "We speak not strictly and philosophically when we talk of the combat of passion and of reason. Reason is, and ought only to be the slave of the passions, and can never pretend to any other office than to serve and obey them." Hume also took his definition of reason to unorthodox extremes by arguing, unlike his predecessors, that human reason is not qualitatively different from either simply conceiving individual ideas, or from judgments associating two ideas, and that "reason is nothing but a wonderful and unintelligible instinct in our souls, which carries us along a certain train of ideas, and endows them with particular qualities, according to their particular situations and relations." It followed from this that animals have reason, only much less complex than human reason
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